Search for: All records

Bulky phenanthroline provides ideal support to stabilize ethylene complexes of copper(i), silver(i) and gold(i), permitting their complete characterization. Copper complexes catalyze the carbene insertion to C–H bonds of adamantane. 

Brightly luminescent, diarylboron decorated, cyclic copper trimers with and without cuprophilic interactions have been synthesized and characterized using multiple techniques including X-ray crystallography. 

In situchemistry of solid silver pyrazolates with ethylene gas, depending on the pyrazolyl ring substituents, stops at a trinuclear complex or leads to complete structure re-organizations producing dinuclear complexes as evident from PXRD data. 

The 3d transition metal (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes, supported by anions of sterically demanding β-diketones, 1,3-dimesitylpropane-1,3-dione (HLMes) and 1,3-bis(3,5-bis(trifluoromethyl)phenyl)-3-hydroxyprop-2-en-1-one (HLCF3), were synthesized and evaluated for their antitumor activity. To assess the biological effects of substituents on phenyl moieties, we also synthesized and investigated the analogous metal(II) complexes of the anion of the less bulky 1,3-diphenylpropane-1,3-dione (HLPh) ligand. The compounds [Cu(LCF3)2], [Cu(LMes)2] and ([Zn(LMes)2]) were characterized by X-ray crystallography. The [Cu(LCF3)2] crystallizes with an apical molecule of solvent (THF) and features a rare square pyramidal geometry at the Cu(II) center. The copper(II) and zinc(II) complexes of diketonate ligands, derived from the deprotonated 1,3-dimesitylpropane-1,3-dione (HLMes), adopt a square planar or a tetrahedral geometry at the metal, respectively. We evaluated the antitumor properties of the newly synthesized (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes against a series of human tumor cell lines derived from different solid tumors. Except for iron derivatives, cellular studies revealed noteworthy antitumor properties, even towards cancer cells endowed with poor sensitivity to the reference drug cisplatin. 

New Cu(i) and Ag(i) phosphane complexes supported by β-diketonate ligands were synthesized and evaluated for their antitumor activity by 2D and 3D cell viability studies.